March 3, 2017

Genetics ‘cloud’ to create new opportunities for researchers and clinicians

Gene sequencing and analysis could be dramatically speeded up, leading to patients receiving a quicker and more accurate diagnosis, thanks to research led by Eagle Genomics Ltd.

Using cloud computing technology, the researchers have found they can slash the amount of time it takes to store the huge amounts of information produced when individual genes are sequenced and analysed.

Whereas at the moment this process can take up to three months, the scientists believe their new technique could mean results are produced in about a week.

Eagle Genomics, a leading open-source bioinformatics service provider, is carrying out the research in collaboration with The University of Manchester, and Cytocell Ltd., with assistance from NGRL, based at the Central Manchester University Hospitals NHS Foundation Trust, and the NIHR Manchester Biomedical Research Centre. The £500,000 project is part-funded by the UK’s national innovation agency, the Technology Strategy Board.

Access to the information analysed and stored by the cloud will enable medical researchers who are developing and testing new treatments to compare large amounts of information and find common genetic links.

The technology will also help clinicians to look at an individual patient’s genetic make-up to aid diagnosis and ongoing treatment.

Rather than simply testing a patient for one suspected condition, using the cloud technology could allow clinicians to test for a much wider range of complaints.

Currently, the NHS IT systems do not have the resources to cope with the huge demands required. The cloud system can be accessed from a separate site, away from hospitals, freeing up space.

The project will build upon the success of the Taverna Workflow Management System software developed by Professor Carole Goble’s myGrid team at The University of Manchester. Eagle Genomics will work with the University to adapt Taverna to allow non-IT experts to easily add and extract information and share it with their colleagues.

“Taverna is ideal for this project because it allows you to systematically automate the analysis processes of expert geneticists and make them easily available for other to use at the press of a button” said Professor Andy Brass of The University of Manchester.

Example applications identified and described by NGRL and Cytocell will provide a significant and valuable resource to help develop and demonstrate the efficacy of the resulting system.

“Genetic sequencing is an increasingly important diagnostic tool as well as being fundamental to many areas of research,” said Professor Graeme Black, Director of the NIHR Manchester Biomedical Research Centre and a consultant at Manchester Royal Eye Hospital.  “By storing genetic data in the ‘cloud’ indefinitely, we can use it for research studies and also to help clinicians to decide if medical conditions, that patients develop at any stage, may be linked to their genes.”

Abel Ureta-Vidal, CEO of Eagle Genomics Ltd., added: “Thanks to funding from the Technology Strategy Board, this project is looking at ways in which genetic data can be securely and confidentially stored, accessed and analysed only by approved users.”

The project, which started in July 2011, is on target for completion of a fully functional system with an initial selection of analyses available by December 2012. 

Notes to editors:

Eagle Genomics Ltd. is an outsourced bioinformatics services and software company specialising in genome content management and the provision of open-source solutions. Eagle consistently delivers quality and value-for-money for customers across the biotech sector, combining cloud and NGS expertise with a track record in building scalable, efficient genomics analysis workflows. www.eaglegenomics.com

The University of Manchester, a member of the Russell Group, is one of the most popular universities in the UK. According to the results of the 2008 Research Assessment Exercise, The University of Manchester is now one of the country’s major research universities, rated third in the UK in terms of ‘research power’. www.manchester.ac.uk

The myGrid team produce and use a suite of tools designed to “help e-Scientists get on with science and get on with scientists”. The tools support the creation of e-laboratories and have been used in domains as diverse as systems biology, social science, music, astronomy, multimedia and chemistry. www.mygrid.org.uk

Cytocell Ltd. is a leading European developer and manufacturer of FISH probes for use in both routine cytogenetics and in the analysis and classification of Cancers. The Company’s products are well established in cytogenetics as the Company is celebrating its 20th year of supplying them to this market. www.cytocell.com

The NIHR Manchester Biomedical Research Centre was created by the National Institute for Health Research in 2008 to effectively move scientific breakthroughs from the laboratory. As a partnership between Central Manchester University Hospitals NHS Foundation Trust and The University of Manchester, the Biomedical Research Centre is designated as a specialist centre of excellence in genetics and developmental medicine. www.manchesterbrc.org

Central Manchester University Hospitals NHS Foundation Trust is a leading provider of specialist healthcare services in Manchester, treating more than a million patients every year. Its five specialist hospitals (Manchester Royal Infirmary, Saint Mary’s Hospital, Royal Manchester Children’s Hospital, Manchester Royal Eye Hospital and the University Dental Hospital of Manchester) are home to hundreds of world class clinicians and academic staff committed to finding patients the best care and treatments. www.cmft.nhs.uk

NGRL provides dedicated support to UK genetic testing centres, focusing on health and bioinformatics, with the aim of bringing new technologies into diagnostic genetics services to the benefit of NHS patients. www.ngrl.org.uk/Manchester

The Technology Strategy Board is a business-led government body which works to create economic growth by ensuring that the UK is a global leader in innovation. Sponsored by the Department for Business, Innovation and Skills (BIS), the Technology Strategy Board brings together business, research and the public sector, supporting and accelerating the development of innovative products and services to meet market needs, tackle major societal challenges and help build the future economy. www.innovateuk.org

For further information please contact:

Richard Holland, Operations and Delivery Director
Eagle Genomics Ltd., Babraham Research Campus, Cambridge
+44 (0)1223 654481 x3 / holland@eaglegenomics.com

Topics: Amazon, Amazon Web Services, AWS, Bioinformatics, Bioinformatics, biological data, changing understanding, clinical, Cloud, Cytocell, Eagle Genomics, genetics, genome content management, health, Manchester, NGRL, NHS, Open source, public cloud, science, Taverna, TSB