Continuing with the abstract series covering the topics at the Eagle Symposium 2015, the following summary was kindly provided by Richard Dobson, Head of Bioinformatics, The NIHR Biomedical Research Centre for Mental Health, Kings College London, who will be addressing the subject of "Harnessing the EHR Beast and Preparing the Way for Genomics - Our Efforts"
Abstract: "In the modern genomic era it is easy to generate lots of data but challenging to integrate findings back into the electronic health record (EHR) to aid clinical decision making. The Centre for Translational Informatics (CTI) was developed to enhance and disseminate practical informatics applications developed at the South London and Maudsley NHS Foundation Trust (SLAM) and the King's College London Institute of Psychiatry, Psychology and Neuroscience (IOPPN). The CTI builds on the Clinical Record Interactive Search (CRIS) application which allows research use of anonymised mental health EHR data on over 250,000 patients at SLAM. I will talk about our progress in phenotyping patients based on natural language processing of the free text records, our Dockerised genomic pipelines for processing of patient data, a few of our biomarker studies in Alzheimer's disease and finally, the use of software multi agents which sit on live EHRs to enable trials in routine clinical practice and improve clinical decisions"
Speaker's Bio: Richard Dobson's main areas of bioinformatics research have focused on the genomics of complex disease, with a special focus on biomarkers of Alzheimer's Disease. His research has required the analysis, integration and modeling of complex large molecular datasets. Richard's group has developed expertise in natural language processing (NLP) for mining electronic patient records (eg. for adverse drug reactions) and they are working on Multi-Agent based computer systems using JADE to exploit big biomedical data for clinician aided decision support and more recently, feasibility work on the use of wearables.
Large collaborative projects include the EU European Medical Informatics Framework (EMIF) for which the group lead on integrative biomarker analysis in Alzheimer's. Other active collaborators include CBITs, Janssen, GE, SomaLogic, Emerald Logic, Illumina, SAGE Bionetworks, TwinsUK, HipSci, GENAROAD and Intel. Richard was previously based at QMW, Microscience (Emergent Biosolutions) and the Sanger Centre. Please visit the group homepage for more.
Eagle Symposium 2015: Eagle Genomics organises an annual industry symposium in the promotion of innovation and advancement in genomics, bioinformatics, and computational biology to help address global issues. The Eagle Symposium 2015 builds on the theme "Bridging Biology and Informatics for R&D Innovation", taking place on 23 March 2015 at the European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus in Hinxton, Cambridge, UK.